Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Mytilene (66% of total searches to Lesbos). The next most popular destinations are Petra (13%) and Anaxos (12%). Searches for hotels in Skala Kallonis (9%) are also popular.
KAYAK users have found double rooms in Lesbos for as cheap as £33 (Mytilene) in the last 3 days. The average price is £119.