Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Havana (49% of total searches to Cuba). The next most popular destinations are Varadero (32%) and Cayo Coco (18%). Searches for hotels in Cayo Guillermo (1%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Cuba is Ciudad de La Habana. Matanzas and Ciego de Avila are also very popular.